Targeting the tumour microbiome to improve response to immunotherapy

Targeting the tumour microbiome to improve response to immunotherapy

Jayde Ngata (Ngai Tahu, Ngāti Porou)

University of Otago, Christchurch

Māori Cancer Researcher Awards - PhD Scholarship

Colorectal cancer affects around 3,000 New Zealanders each year, with Māori patients experiencing poorer outcomes compared to non-Māori. Immunotherapy is a new type of cancer treatment that uses the body’s immune system to fight cancer. While immunotherapy has shown promise in treating some cancers, it is effective in only about 4% of advanced colorectal cancer cases. This research project aims to uncover the reasons behind the limited effectiveness of immunotherapy in colorectal cancer, with a particular focus on the role of bacteria in these tumours.

Research from our group has identified bacteria within colorectal tumours that influences the immune system's response to immunotherapy. Building on these initial findings, the project will expand the research by analysing patient tumour samples and developing lab-grown tumour models. In addition, the study will include qualitative research to engage Māori patients and their whānau about their experiences with tissue donation for research, ensuring the process is culturally safe, respectful, and aligns with the principles of the Meihana Model.

By exploring how bacteria might improve immunotherapy responses, this research aims to enhance outcomes for Māori patients and reduce health disparities in colorectal cancer care. The ultimate goal is to develop more effective, accessible cancer therapies that benefit all New Zealanders—especially Māori—and foster equitable cancer care for everyone.